MSD may refer to any of the following:

  1. Short for Most Significant Digit, MSD is the digit to the far left in a string of digits. For example, in the number 2006, the “2” is the most significant digit.

  2. MSD is short for Microsoft Diagnostics. See Microsoft Diagnostics for definition.

  3. MSD is short for Moscow Summer Time.

Computer acronyms, Digit, Least significant digit, Most significant bit, Most significant byte, Most significant character, Software terms